Wilms tumor (nephroblastoma) – clinical and genetic aspects

Nephroblastoma (Wilms tumor – WT) is the most common kidney among pediatric population, fifth malignant neoplasms and third solid tumors. The type of WT sporadic unilateral. occurs either as an isolated, nonsyndromic or syndromic one belonging to spectrum a variety genetic syndromes. Molecular testing should be considered in include multigene panel whole exome sequencing (WES); cases single-gene testing, DNA methylation chromosomal microarray. Outcomes treatment patients remain very good, but there are still subgroups with poor prognosis increased relapse rates, especially blastemic disseminated anaplasia types. survivors have risk chronic disease (CKD). They need further follow-up, not only by oncologists also nephrologists, preserve function slow down CKD progression.